1. 研究目的与意义（文献综述包含参考文献）
1-IntroductionTalin-1 is a cytoplasmic protein that is encoded in humans by TLN1 gene. It has a molecular weight of 270 kDa (2541 amino acids).[1,2] Talin-1 is localized to costamere structures in cardiac and skeletal muscle cells, and to focal adhesions in smooth muscle and non-muscle cells. Talin-1 is expressed mainly in the kidney, liver, spleen, stomach, lung and vascular smooth muscle and its overexpression can promote prostate cancer cell adhesion, migration and invasion. [3-5]. Talin-1 functions to mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of integrins. . As a result of activation, integrins increase cell-to-extracellular matrix (ECM) interactions, so transduce bidirectional signals and finally regulating adhesion, cell growth, apoptosis, and tumor growth (Fang et al., 2014). Altered expression of talin-1 has been observed in patients with heart failure, however no mutations in TLN1 have been linked with specific diseases.
2. 研究的基本内容、问题解决措施及方案
1）review on the liver disease related Talin-1 and the signal;2) data analysis for proteomics.
