炎症微环境在肝纤维化中的作用机制及研究进展
摘要：肝纤维化是慢性肝病重要的病理特征，也是进一步向肝硬化发展的主要中间环节，
是影响慢性肝病预后的重要环节。目前尚不明确异甘草酸镁防治慢性肝病的分子机制。异甘草酸镁作为第四代甘草酸制剂，与以往的甘草酸制剂相比, 在调节酶活性方面具有明显的优势，而且已有的研究显示其较以往的甘草酸制剂有更好的疗效和安全性，但是目前尚不明确异甘草酸镁防治慢性肝病的分子机制。本文立足于肝纤化近几年的最新研究成果，阐述异甘草酸镁在炎症微环境中的作用，以及对肝纤维化的调控作用及分子机制。
关键词:异甘草酸镁；肝纤维化；炎症因子；肝星状细胞；分子机制
Abstract: Hepatic fibrosis is an important pathological feature of chronic liver disease and it is also the main intermediate link for further development of liver cirrhosis. It is an important link that affects the prognosis of chronic liver disease. It is not yet clear that the molecular mechanism of magnesium isoglycyrrhizate (MgIG) in the prevention and treatment of chronic liver disease. MgIG, as the fourth generation of glycyrrhizic acid preparation, has obvious advantages in the regulation of enzyme activity compared with the past glycyrrhizic acid preparation. Previous study have shown that MgIG had better efficacy and safety than previous glycyrrhizin acid preparation, but it is not clear the molecular mechanism of MgIG in prevention and treatment of chronic liver disease. Based on the latest research of liver fibrosis , this paper expounds the effect of MgIG in inflammatory microenvironment, and its regulation and molecular mechanism in liver fibrosis.
