阿托伐他汀致肝功能异常的危险因素分析
[关键词] 他汀类药物；阿托伐他汀；肝损害，药物性；危险因素
[摘要] 目的 探讨阿托伐他汀致肝功能异常的危险因素，指导临床为患者提供药学监护，保证临床安全合理用药。方法 选取2013年1月至12月使用阿托伐他汀钙片且资料完整的500例患者作为研究对象。选择对肝功能可能产生影响的相关因素，进行chi;2检验单因素分析和Cox多因素分析。结果 肝功能异常的发生率为5.4%（27/500）。经单因素和多因素分析后显示，年龄ge;60岁、饮酒ge;500 g·周-1、合并用药（胺碘酮）与肝功能异常有关，是阿托伐他汀致肝功能异常的独立危险因素。结论 老年人，饮酒和合并用药（胺碘酮）是阿托伐他汀致肝功能异常的危险因素，选用他汀类药物时应结合患者的个体情况，保证用药安全。
Risk factors of hepatic dysfunction induced by Atorvastatin
Zhangjinyang
（Department of Pharmacy, Yangpu Hospital of Tongji University, SHANGHAI 200090, China）
[KEY WORDS] Statins；atorvastatin； Liverinjury，drug-induced；Risk factors
[ABSTRACT] AIM To explore the risk factors of hepatic dysfunction caused by atorvastatin, and to provide pharmaceutical care for patients，ensure the safety of clinical drug use. METHODS Select the use of atorvastatin and 500 cases with complete data as the research object during 2013.1 to 2013.12. Univariate and Cox multivariate regression analysis was performed on the related factors of liver function. RESULTS Hepatic dysfunction occurred in 5.4%(27/500). Univariate analysis and Muitivariate analysis revealed that agege;60years, drinkingge;500g/week, drug combination (amiodarone) related to hepatic dysfunction, were independent risk factors for atorvastatin induced hepatic dysfunction. CONCLUSION The elderly, drinkingge;500g/week, drug combination (amiodarone) is the risk factors for atorvastatin induced hepatic dysfunction,we should combine the individual condition of patients in the use of statins,to ensure the safety of statins.
