开题报告内容：（包括拟研究或解决的问题、采用的研究手段及文献综述，不少于2000字）目的：现代医学界中少有像阿尔兹海默症这样同时获得公众关注和科学家们的关心。
值得注意的是，世界上阿尔兹海默症患者早已突破4000万，而其确诊后的预期存活寿命在3年到10年。
虽然有些能暂时减缓症状，但至今也没有多少能防范或者翻转其过程的治疗手段。
更重要的是，其中详细的机制也还有待发现，更不用说从其中衍生出的有效治疗方法了。
近些年大量与Abeta;机制有关的新药研发都在四期试验前被叫停。
因此我们需要用不同于过去的新思路来研究可能的疗法。
而最近对葡聚糖的一些研究表明其对阿尔兹海默症有一些积极的作用。
本实验主要在细胞级别验证葡聚糖对阿尔兹海默症模型小鼠的学习损伤的保护作用并寻找其中的机制，旨在进一步研究成为预防或减轻甚至治疗阿尔兹海默症患者的策略。
Purpose: Few diseases in modern medicine have accrued such public concern and scientific interest as alzheimers disease(AD) does. Notably, the prevalence of AD has climbed to over 40 million patients, and the life expectancy after definite diagnosis ranges from 3 to 10 years. Up till now, there is lack of treatment that is able to prevent or reverse the progression, although some may tentatively alleviate symptoms. On top of that, the particular mechanism is poorly understood, let alone valid therapies stem from the pathogenesis. Loads of new Abeta; pathogenesis-related-drug development have been called a halt before phase four trials through last few decades. Hence new pattern, other than past Abeta; relevant strategies, of possible treatment needs to be studied. Recent researches have indicated some positive effect of glucan towards AD.To verify the neuroprotective effect of glucan to AD model mouses study impairment mainly in cell level and find its mechanism, we aim to further study and make it the precautionary or alleviation or therapeutic strategy to AD.研究内容：首先要进行对研究细胞的选择，培养性质合适的相关细胞，再调整其中Abeta;浓度，确定阿尔兹海默症模型小鼠脑中浓度水平，细胞分组，空白组，对照组，实验组，以适宜条件培养到传代稳定，接着给予干预物，即葡聚糖，观察不同时间的不同现象，检测其中Abeta;浓度变化，再摸索不同葡聚糖浓度对同一细胞组的Abeta;浓度影响。
