GABAB受体别构正向调控剂CMPPE的抗焦虑和抗抑郁效果评价文献综述

文献综述

随着社会压力的增加，精神疾病的发病率也与日俱增。其中，焦虑症和抑郁症是最常见的精神障碍之一。研究表明，多种神经递质与其受体都参与焦虑症和抑郁症的发生与发展之中。例如，gamma;-氨基丁酸（GABA）和受体在焦虑症和抑郁症中发挥着非常重要的作用，是非常好的干预靶点。GABA受体包括多种亚性，主要分为GABAA受体、GABAB受体、GABAG受体。研究表明，敲除GABAB受体可以导致动物焦虑行为的产生，说明GABAB参与调节焦虑行为。

该研究的开展将系统地评估CMPPE是否具有抗焦虑和抗抑郁的作用。该临床前研究将为CMPPE可能作为抗焦虑和抗抑郁的新型药物应用于临床提供理论支持。同时，研究的结果将为我们进一步在慢性应激模型导致的焦虑和抑郁中评价CMPPE的作用提供基础。

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